De Beursvloer #84: Weekend!

quote:

Op maandag 27 april 2009 11:20 schreef Bolkesteijn het volgende:

[..]

Dat is dan dom van de heren analisten, want antibiotica werkt niet tegen griepvirussen. En verder zijn virusremmers juist al op grote schaal ingekocht door tientallen landen, die omzet is dus al geweest.

quote:

Op maandag 27 april 2009 11:26 schreef edikt het volgende:
Het werkt wel tegen griepvirussen en is daarmee ook te behandelen. Er is alleen nog geen vaccin.

quote:

World counting down to pandemic, says top virologist
Mon Apr 27, 2009 12:43am EDT

By Tan Ee Lyn

HONG KONG (Reuters) - A Chinese virologist who helped fight SARS and bird flu warned on Monday of a possible swine flu pandemic that the most populous countries in Asia, China and India, would be ill-prepared to handle.

"We are counting down to a pandemic," said Guan Yi, a professor at the University of Hong Kong who helped trace the outbreak of SARS in 2003 to the civet cat.

"I think the spread of this virus in humans cannot possibly be contained within a short time ... there are already cases in almost every region. The picture is changing every moment."

Guan, who has been studying and tracking the spread of the H5N1 bird flu virus ever since it was discovered in people in Hong Kong in 1997, said there would be "many problems" if swine flu reached China and India, "where populations are so dense and health infrastructure is still insufficient."

The virus, which carries swine, avian and human DNA and the designation H1N1, has already killed up to 103 people in Mexico, infected 20 in the United States and six in Canada.

There are many questions surrounding this virus, such as why it appears milder in the United States and deadlier in Mexico.

"It may seem weaker for now in the United States, but we do not know if it will get more virulent when it goes to another place as it mutates constantly," said Guan.

"When it goes into a place like China, there will be very high transmissibility among people."

Microbes like viruses mutate all the time and can swap or mix DNA with other viruses they come into contact with. And nobody knows whether they could become more or less deadly, experts say.

Guan said the swine flu virus was very different from the seasonal human H1N1 flu virus.

"It is almost a new subtype," he said, adding that as it was already transmitting efficiently among people, the world already had a pandemic on its hands.

Currently the World Health Organisation classifies the virus as a "public health emergency of international concern" that could become a pandemic, or global outbreak of serious disease.

"This is what I am very worried about. The WHO is always very cautious (about raising its alert system) but it is wasting time," Guan added.

The current phase of alert is 3 on a scale of 1 to 6. A full-blown pandemic, level 6, denotes sustained human to human spread over many countries of a new and serious virus.

(Editing by Chris Lewis and Nick Macfie)

quote:

Op maandag 27 april 2009 10:31 schreef Lemans24 het volgende:

[..]

Dus JIJ heb dat virus geconstrueerd?

quote:

Op maandag 27 april 2009 11:19 schreef foetre het volgende:
Ik denk dat klm vandaag nog wel onder de 8 euro komt.Is dat een mooi punt om wat te kopen of gaat ie nog een stuk lager?

quote:

Op maandag 27 april 2009 11:34 schreef Lemans24 het volgende:

[..]

Ik heb ze een aantal weken geleden verkocht op 7,02. Graag weer eens onder de 7 dus!

quote:

Op maandag 27 april 2009 11:30 schreef Bolkesteijn het volgende:

[..]

Antibiotica helpen niet tegen virussen, maar alleen tegen bacterieen.

quote:

Op maandag 27 april 2009 11:14 schreef lammegiraf het volgende:
longetjes eruit @10%

quote:

Op maandag 27 april 2009 11:31 schreef pberends het volgende:

[..]

Nee. Ik heb het virus verspreid bij Mexicaanse sletjes.

quote:

Op maandag 27 april 2009 12:12 schreef rvlaak_werk2 het volgende:
Volgens Jos Versteeg daalt de beurs vanwege "het virus"... Lijkt me een beetje sterk dat dit de enigste reden is, gezien de rest van de economie.

quote:

Op maandag 27 april 2009 12:40 schreef UncleSam het volgende:
KPN stijgt weer
Op naar koersdoel 14 EUR!

http://www.telegraaf.nl/d(...)ing_KPN__.html?p=7,1

quote:

Op maandag 27 april 2009 13:19 schreef pberends het volgende:
Die intragay grafiek van Pharming Group NV .

wtf gebeurde daar nu...

quote:

Op maandag 27 april 2009 13:20 schreef rvlaak_werk2 het volgende:

[..]

Plaatje? Kan m nl ff niet vinden

quote:

Op maandag 27 april 2009 13:25 schreef pberends het volgende:

[..]

smallcap...

quote:

Op maandag 27 april 2009 13:30 schreef pberends het volgende:
[ afbeelding ]

Zeker een vaccin tegen varkensgriep...

quote:

Prodarsan® Granted Orphan Drug Designation From FDA


Leiden, The Netherlands, April 27, 2009. Biotech company Pharming Group NV (“Pharming” or “the Company”) (NYSE Euronext: PHARM) announced today that its wholly owned subsidiary DNage BV (“DNage”) has received a notice from the US Food and Drug Administration (“FDA”) that its product Prodarsan® has been awarded an Orphan Drug designation for the treatment of Cockayne Syndrome. Prodarsan® is a combination of two small molecules, formulated for oral use, which are believed to reduce the accumulation of DNA-damage, the underlying biochemical cause of Cockayne Syndrome.

Cockayne Syndrome, the initial target of Prodarsan®, is a rare genetic disease in which children suffer from accelerated (or premature) aging, while developing severe aging diseases. Progeria diseases are a group of genetic premature aging d iseases which manifest in several forms that are genetically and clinically similar although not identical. Depending on the specific form of the disease, patients have a significantly reduced life expectancy and exhibit many aging-related symptoms early on in their lives. Quality of life for these patients is seriously impaired. Cockayne Syndrome is one of the more common forms of progeria and is characterized, among others, by growth failure, mental retardation, hearing and sight problems and a reduced life expectancy. Currently, no effective therapy for Cockayne Syndrome is available.

DNage has demonstrated that Prodarsan® has significant beneficial effects in animal models for Cockayne Syndrome. Furthermore, it has shown that the product was safe and well-tolerated in a study in human volunteers. In consultation with the FDA, the Company is now preparing to submit an IND (Investigational New Drug) Application that will allow the initiation of additional c linical studies in patients. The Principal Investigator in these planned international studies is Dr. Edward Neilan, Staff Physician at Children's Hospital Boston / Harvard Medical School, a world renowned clinician and researcher in the field of Cockayne Syndrome.

Dr. Neilan commented: ”Based on discussions with the FDA and the designation of Prodarsan® as an Orphan Drug, I believe we are making important progress in finding new treatment modalities for this severe disease. My interactions with many patients and their families have convinced me that there is a very strong medical need for new treatments. I look forward to leading the further clinical investigation of this potential new medicine together with several colleagues in the USA and Europe and hope that the promising data in animals and human volunteers will hold up in Cockayne Syndrome patients as well.”

The FDA’s Orphan Drug designation is reserved for new therapies being developed to treat diseases or conditions that affect fewer than 200,000 people in the United States. The Orphan Drug designation provides for an accelerated review process, tax benefits, exemption from user fees and a seven-year period of market exclusivity in the US after product approval. The designation is awarded based on an application describing the disease, the product and an extensive outline of the proposed development plan. The application for Prodarsan® was filed by Clinquest, DNage’s agent in the USA.

quote:

Op maandag 27 april 2009 13:52 schreef One_conundrum het volgende:

[..]

kan nog geen Nederlandse vinden

quote:

The term orphan drug refers to a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease. The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries, and has resulted in medical breakthroughs that would not have otherwise been achieved due to the economics of drug research and development.

quote:

Op maandag 27 april 2009 13:54 schreef One_conundrum het volgende:

[..]

Volgens wiki

http://en.wikipedia.org/wiki/Orphan_drug