Melanotan. Bruin worden van binnenuit.

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Well I have bad news embarrassed
I am dealing with some very serious health problems. I think I am the next Sunless Princess! undecided(see melanotan one logs).
After stopping my cycle my weight started to go down for the first two weeks just by a bit so I hoped this would continue. But it didn't it continued to increase at an alarming rate. I couldn't understand this as I had been on a very strict diet and despite not being able to do cardio exercise my job is very active so it made no sense, at the worst it should have been staying stable. The chest pains, breathing problems and breast pain (which began to decrease) all started getting worse. The blurry vision which started when I started my cycle, mainly on the days I injected, is now almost all of the time and I can only look at a computer screen or read for ten minutes before it gets very bad. Never had problems with my sight before.The joint pain is now all over my body as is the muscle pain and am having cramps and muscle spasms too. The dry skin on my feet became a serious fungal infection which spread to my hands and has lead to each nail becoming unattached by half of the nail on hands and feet. I have treated it and it has stopped spreading. I am having very irregular sleep patterns, problems getting to sleep then waking often and then problems getting back to sleep even when very tired. Even if I sleep 8 hours I wake up exhausted and feel sleepy all day. I have had constipation one day then upset tum the next for a while now. I am suffering from regular memory loss long and short term and sometimes not being able to think of the right word I am looking for, feeling stupid. I am having a lot of days of feeling depressed, anxiety every day and feeling of panic and negative thoughts.

All of these symptoms were NOT present before I began Melanotan II. The only one which was similar was that I was over weight but that had been a constant weight rather than rapidly increasing. I had tried to explain each symptom by something other than Melanotan II ie. fungus maybe due to washing my hands too often. But it got to the point where I couldn't find any explanations so I booked a doctors appointment and started searching the forum. That's when I found Sunless Princess' log and was shocked at how similar our symptoms were and how serious it could become.

She mentioned having WTS (Wilson's Temperature Syndrome) which I then did a lot of research on and it is something which 40% of us can have at some point in our lives and is triggered by a shock to the body/system. The test is simple using a thermometer to check the temperature 3 times a day at certain times and if it is consistently below 37 degrees it is a sign you have this syndrome. Other things must be ruled out aswell but it is treatable over a period of months/years with strict medication. All of the symptoms I have are explained by this syndrome (if that is what I have).

So I went to my doctor today and told him everything including about using Melanotan II and when I stopped my cycle etc. He was shocked by all the symptoms since I had seen him in July for a regular checkup and all was fine except for the weight increase (and I hadn't been to a doctor in 6 years!) but he has taken it all seriously and I have appointments for full blood work and other tests. I must continue checking my temperature at the given times and if nothing is found in the tests he will look into treatment for WTS.

I have a very stress free lifestyle, am my own boss and have a lot of time off to relax so I have no reason to feel anxious and have all these symptoms. The only thing that changed was the use of Melanotan II.

So the question is, "Is Melanotan II the cause?"
It is very possible but not in the way you might think. WTS is caused by a shock to the body, such as a death, divorce, work stress, giving up smoking, use of a medication, suddenly stopping eating even having an operation and various other stressful stuff.
Basically the body defends itself against the threat to the system by going into "hibernation mode" and begins functioning at a lower temperature. The body's organs don't function as well at this temperature which is why it causes all the problems but it is the body's way of saving energy and surviving. Most people who go through this go back to normal but a lot of us don't and some can stay like this forever never knowing what is causing the problems since they are looking at them all as individual problems not realising they are all related. Some people have a trauma and never feel the same again physically or mentally and it could be because they have WTS.
It is not fatal but can lead to early death due to heart failure etc.

Sunless Princess could not say 100% that it was caused by Melanotan but the symptoms began when she began her cycle(this is the same for me) and are beginning to go away with the treatment but is a lengthy procedure. If Melanotan is the cause it may not be because it is bad , or has something wrong with it but because it may be the substance which has shocked the body as it is unused to it creating the problem or the act of injecting has caused the stress and lead to the problem. So a lot of us may not be affected but then many of us could be and some of us may be affected at first but the body resets itself making the symptoms go away. This could explain why some have side effects just at the beginning when we just presume it is because the body has got used to it. I too feel very sad that I finally discovered something that can give me a tan and make me feel more confident but may have lead to all these problems, I am absolutely gutted! cry

I think the main problem here is that many of us will experience side effects during a cycle, not realise they could be something serious and presume they will go away after usage stops. But if it is ignored it can lead to serious problems which will be permanent and even get worse if left untreated.
I know this is what I did and since they mainly got much worse after I stopped the cycle I presumed that they mustn't be related. However it could be that my body was more shocked by the sudden withdrawal of the Melanotan II as oppose to when I began usage. Many people on this site have experienced chest pain, breathing problems, blurred vision, insomnia, joint pain, muscle ache, lethargy, weight changes, constipation/upset tum, fungal infections, loss of appetite, under performance at the gym, pain in breast tissue, anxiety, depression. These are all symptoms of either WTS or a malfunctioning thyroid(which can be caused by WTS) or both at the same time. But we are all just thinking they are temporary side effects.

Anyway, this is a bit longer than I planned. I will keep you posted on my results and anything else I find out. I have PM'd Sunless Princess but not had a reply yet, maybe she will see this and post. I advise anyone who is experiencing these symptoms during or after a cycle to seek medical advice and insist on tests just incase. undecided

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Op zondag 8 juli 2007 01:31 schreef cinnamongirl het volgende:

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Makkelijk praten als je van jezelf goed bruin kan worden...
Voor mensen met huidtype I: een zeer lichte huid die snel verbrandt is zoiets echt een uitkomst...
Ik zou het heel erg prettig vinden als ik eens een keer langer dan 5 minuten in de zon kon zitten zonder me steeds eerst vol te moeten smeren met factor 1000.
En dat ik bij de eerste zonnestralen gewoon een rokje en een hemdje aan kan doen en naar buiten kan gaan, zonder dat ik eerst dagen moet gaan smeren met zelfbruiners e.d. omdat die witte melkflessen echt geen gezicht zijn.

Maar goed; ik waag me er (nog) niet aan; er is nog te weinig bekend over de effecten op lange termijn.

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Op dinsdag 3 maart 2009 23:47 schreef melanotan het volgende:
Melanotan-1 "afamelanotide" / FDA : Suntan Drug Greenlighted for Trials

Ciao

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A drug that stimulates the body's tanning response — turning pasty skin caramel for up to two months — has been approved for human trials, but not for tanning.

Although the drug will not be available for cosmetic purposes any time soon, similar compounds are already being widely abused on the pharmaceutical black market. The official product, a man made hormone called afamelanotide, has received U.S. government approval to begin clinical trials.

"It's a bioabsorbable implant that you just inject into the skin," said Colin Mackie, director of business development for Clinuvel, the company bringing the drug to the U.S. "It stimulates melanin production."
Melanin is the body's natural pigment. It's responsible for the color of skin and protects humans from harmful solar radiation. The drug will be tested as a treatment for patients who face serious danger from the sun's rays, like those with rare genetic diseases or who must take immunosuppressants, Mackie said.
But online retailers already offer a similar (but not identical) compound under a more descriptive brand name, Melanotan II, which American and British health officials warn are already being abused.

"Using it could be dangerous to short and long-term health," British health officials said in November. It has not been tested for safety, quality or effectiveness and we don't know the potential side effects yet."
This week two British Medical Journal researchers warned that injecting the compound could change the size and shape of moles, which under normal circumstances can be a precursor to skin cancer.

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Op vrijdag 17 juli 2009 15:10 schreef zeezout het volgende:

Dit kan echt niet goed voor je zijn.

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Melanotan II is a synthetic analog of the naturally occurring peptide hormone alpha-melanocyte stimulating hormone (α-MSH) that has been shown to have tanning and aphrodisiac properties in preliminary studies and clinical trials.

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Melanotan II was first synthesized at the University of Arizona. Researchers there knew that one of the best defenses against skin cancer was a natural tan which has been slowly developed over weeks. They hypothesized that an effective way to reduce skin cancer rates in people would be to induce the body's natural tanning system to produce a protective tan prior to UV exposure. The body's naturally occurring hormone α-MSH causes melanogenesis, a process by which the skin's tanning cells (melanocytes) produce the skin's tanning pigment (melanin). They tested to see if administering this endogenous hormone to the body directly could be an effective method to cause sunless tanning. What they found was that while it appeared to work, natural α-MSH had too short a half life in the body to be practical as a therapeutic drug. So they decided to find a more potent and stable alternative, one that would be more practical.

After synthesizing and screening hundreds of molecules, the researchers headed by Victor Hruby, found a peptide, [Nle4, D-Phe7]-α-MSH, that was approximately 1,000 times more potent than natural α-MSH. [5] They dubbed this new peptide, "Melanotan" (later Melanotan I, now known as afamelanotide). They subsequently developed another analog, Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2), which they called "Melanotan II". Since their discovery, numerous studies dating back to the mid-1980s[5] have found no obvious toxic effects of the Melanotan peptides. The scientists hoped to use Melanotan peptides to combat melanoma by stimulating the body's natural tanning mechanism to create a tan without first needing exposure to harmful levels of UV radiation. [6] This in turn, they hypothesized, could reduce the potential for skin damage that can eventually lead to skin cancer.

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Op vrijdag 17 juli 2009 15:23 schreef DennisMoore het volgende:

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http://en.wikipedia.org/wiki/Melanotan_II
[..]


[..]

Ik wil graag een bescheiden kleurtje (dunne mensen zien er helemaal wit wat te ongezond uit vind ik), maar ik heb geen zin om me maandelijks of wekelijks met UV-stralen te laten bombarderen. Risico's op huidkanker, veroudering van de huid, etc.

Dus van binnenuit vind ik wel een goed idee , iig om eens te proberen.

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Drug agency warnings

In 2007, the FDA issued a warning to an American vendor illegally marketing melanotan II on the internet as a drug that prevents skin cancer and assists tanning. The FDA has not licensed melanotan II, and explained: "There is no evidence that the product is generally recognized as safe and effective [GRAS/E] for its labeled uses." The FDA concurrently gave a blanket warning advising consumers to, "stop using Melanotan II, an unapproved product".[11]
On August 8, 2008 the Danish Medicines Agency (DMA) issued a warning[12] against the usage of Melanotan purchased on the internet, noting that claims that imply that it has an, "effect" for protection against skin cancer, "has not been documented". The DMA further warned that Melanotan has not undergone tests for its effect and possible side effects, and that it is not licensed for usage in the EU or the USA.
The UK Medicines and Healthcare products Regulatory Agency issued a similar warning on November 17 2008[13] stating that "We are warning people not to use this product. Don’t be fooled into thinking that Melanotan offers a shortcut to a safer and more even tan. The safety of these products is unknown and they are unlicensed in the UK. The side effects could be extremely serious. If you have used either of these products do not use them again and if you have any concerns you should seek advice from your doctor.

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Op vrijdag 17 juli 2009 16:51 schreef koffiekoekje het volgende:

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En uit dat zelfde artikel....
[..]

Of wil je dat niet weten

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Op vrijdag 17 juli 2009 17:43 schreef DennisMoore het volgende:

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Ja, dat zei ik dus al. De enige kritiek is van officials die roepen dat het officiële stempeltje ontbreekt. Inhoudelijk zeggen ze niets.

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Op vrijdag 17 juli 2009 18:56 schreef koffiekoekje het volgende:

Er is geen bewijs dat het geen kwaad kan .... en geen bewijs dat het werkt tegen huid kanker ... en niet getest op mogelijke bijwerkingen.

Inhoudelijker dan dat hoeft het voor mij ook niet te wezen qua veiligheid en betrouwbaarheid

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Op vrijdag 17 juli 2009 23:19 schreef DennisMoore het volgende:
D'r is wel een bijwerking trouwens die niet helemaal onprettig is .
Maar dat zou ook aan 't warme weer kunnen liggen...

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Op zaterdag 18 juli 2009 06:26 schreef Orlistat het volgende:

Het maakt je geil?

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Op zaterdag 18 juli 2009 12:08 schreef DennisMoore het volgende:
Het is nu al een uitkomst voor veel mensen, als je de fora leest. Mensen die eerst niet een kwartiertje in de zon kunnen zonder gelijk te verbranden, hebben nu geen last meer en worden zelfs een beetje bruin.

Cosmetisch gebruik, puur om bruin te worden, is natuurlijk slechts luxe en geen noodzaak. Maar als die mensen anders continu in de zon en zonnebanken liggen te bakken om bruin te worden, lijkt me dit minder ongezond.

Je wordt namelijk al bruin van gewoon zonlicht namelijk. M'n handen en gezicht (blootgesteld aan daglicht) waren al flink bruin zonder dat ik bewust ben gaan zonnen of onder de zonnebank heb gelegen.

'k Weet niet hoeveel je zou moeten gebruik waardoor het effect heeft op je haarzakjes (dat is het dan toch?), waardoor de haren die eruit groeien donker gaan worden... Ik gebruik dus de helft van de 'aanbevolen' hoeveelheid, en ik merk wel dat m'n moedervlekken veel donkerder zijn geworden, en dat ik er nu ook een paar bij heb die eerst blijkbaar onzichtbaar waren.

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Op zaterdag 18 juli 2009 12:22 schreef Onbepaald het volgende:

Het is natuurlijk een afweging (voordelen / nadelen) die je moet maken. Een afweging die mensen niet maken als ze onder de zonnebank gaan, terwijl dat (ook) schadelijk kan zijn. Ik denk wel dat dit een grote hit gaat worden als het bekend(er) wordt. Heb je toevallig before / after foto's van jezelf of zet je deze liever niet op een openbaar forum? Ik vind het namelijk nog steeds een interessant goedje.

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Op zaterdag 18 juli 2009 13:01 schreef Lamon het volgende:
Okee, dan maar naar dit topic, maar je krijgt er dus wel een versterking van je moedervlekken van, dat had ik al eerder gehoord?
Maar dus geen nieuwe vlekjes die er eerder nog niet waren?

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Op zaterdag 18 juli 2009 12:08 schreef DennisMoore het volgende:
Ik gebruik dus de helft van de 'aanbevolen' hoeveelheid, en ik merk wel dat m'n moedervlekken veel donkerder zijn geworden, en dat ik er nu ook een aantal bij heb die eerst blijkbaar onzichtbaar waren.

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Op zaterdag 18 juli 2009 13:01 schreef Lamon het volgende:

Maar dus geen nieuwe vlekjes die er eerder nog niet waren?

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En je haar wordt donkerder, dat wist ik al, maar ja, als je een lekker kleurtje hebt, maakt dat natuurlijk geen klap uit.

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Op zaterdag 18 juli 2009 12:54 schreef Richel het volgende:

Ik heb wel serieuze interesse in het product, kun je niet je e-mailadres hier plaatsen?

Dan stuur ik je een mailtje. .

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Op zaterdag 18 juli 2009 14:25 schreef DennisMoore het volgende:

Je kunt kijken op 't forum op www.melanotan.nl, daar staat ook een advertentie van een webshop.

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Op zaterdag 7 juli 2007 23:59 schreef Yzord het volgende:
Absoluut geen nep bruin...vergeet niet dat wat normaal de zon stimuleert, nu dat spul het doet. Dus niks geen beta caroteen of nep uv van zonnebank.

En je wordt geleidelijk bruin...als je je te bruin vindt worden, dan stop je ermee. Er met 30mg doe je drie weken ongeveer, en dat is meer dan zat.

Ik ben mijn derde kuur al aan het plannen

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Op zaterdag 18 juli 2009 18:28 schreef Parafernalia het volgende:

150 euro voor 3 weken bruin zijn?

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Op vrijdag 17 juli 2009 21:32 schreef DennisMoore het volgende:

Nogmaals: inhoudelijk zeggen ze er niéts over. Waarom zou het gevaarlijk zijn? Wat kun je ervan krijgen? Wat zou het doen met de huid? Is het giftig? Zijn er mensen ziek van geworden? Etc etc. Nee dus.

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Op zaterdag 21 juli 2007 00:23 schreef Aventura het volgende:
Nu ga ik zeker wachten tot testfase III van Clinuvel gereed is. Er gaan nu verhalen over oogschade de ronde. Dat is 't toch echt niet waard

http://melanotan.org/cgi-bin/yabb/YaBB.pl?num=1183897770/0

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Op zaterdag 18 juli 2009 19:41 schreef Richel het volgende:

En die oogschade dan op de langere termijn?

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Given the dearth of similar reports from the nearly 5,000 registered forum members and the fact that spontaneous occurrences of CSR are fairly common (although it's cause is unknown) in males between the ages of 20 to 50, the link to melanotan II as a cause in this case is highly highly doubtful. Also the fact that Robbie never came back to give us an update on this increases the doubtfulness.

Relative to the majority of strange issues reported by peptide users, I am inclined to agree with scoparli when he posted this:

Quote from scoparli4 on 07/22/08 at 04:21:53:
i think its all anxiety. anxiety can cause some crazy shit to occur. i know first hand. injecting this shit into with all this hysteria is putting you in a high level of anxiety whether you recognize it or not.

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Company Announcement
Tuesday 20th March 2007
Melbourne, Australia
New Oncology application identified for CUV1647
Clinuvel Pharmaceuticals Limited (ASX:CUV, XETRA-DAX:UR9) is pleased to announce that it has identified a new oncology application for CUV1647. CUV1647 stimulates an increase in the production of the body’s natural photoprotective pigment, melanin. It is anticipated that CUV1647 will be shown to prevent the phototoxicity associated with Photodynamic Therapy (PDT) in cancer therapy.
Clinuvel has filed patent applications for the use of CUV1647 and any related compounds that serve as photoprotective agents for patients who have undergone PDT treatment.
This announcement further advances the company’s strategy to diversify the target medical indications for CUV1647. Applications to begin clinical trials in this new indication will soon be filed.
Background to Photodynamic Therapy
The four most common cancer therapies are surgery, radiotherapy, chemotherapy and photodynamic therapy (PDT).
PDT was first used as a cancer therapy over 100 years ago. PDT uses laser, or other light sources, combined with a light sensitive drug (called photosensitising agent) to destroy cancer cells. This treatment is used in many cases where surgery is neither possible nor preferred. PDT is most frequently used in gastro-intestinal, esophageal, bladder, neurosurgical, prostate cancers/disorders and in wet age-related macular degeneration of the eyes.
One of the limiting factors and key side effects of PDT therapy is debilitating photosensitivity of skin and eyes to light (sunlight as well as artificial light). Patients suffer intense pain associated with this photosensitivity and are forced to avoid sunlight/artificial light for up to 90 days following treatment.

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Op zaterdag 18 juli 2009 23:01 schreef Pumatje het volgende:
ik vind het echt wonderbaarlijk dat jullie zover gaan dat jullie het product overwegen te gebruiken met zulke berichtgevingen erover