Vaccins #5 - Het zal in Q1 2021

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Op woensdag 30 december 2020 07:18 schreef Gia het volgende:
Het Oxford-vaccin is volgens testen minder doeltreffend dan pfizer en moderna. Houdt dat dan in dat kwetsbaren eerder pfizer of moderna krijgen en de grote hoop gezonden onder de 60 later het Oxford?

Zou mij namelijk logisch lijken.

En heb je er zelf ook nog wat over te zeggen?

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Op woensdag 30 december 2020 11:41 schreef George_of_the_Jungle het volgende:
https://www.theguardian.com/society/2020/dec/30/oxford-astrazeneca-covid-vaccine-approved-by-uk-regulator

Paar opvallende punten:
-Niemand die het vaccin heeft gekregen is opgenomen geweest in het ziekenhuis met Covid, dus nog steeds 100% bescherming tegen ernstige Covid.
-Men gaat zo snel mogelijk iedereen 1 keer vaccineren en daarna pas een tweede keer, dit om zo snel mogelijk kwetsbaren te beschermen, het doel is in maart alle 9 kwetsbare groepen te hebben gevaccineerd.
-Distributie start vandaag of morgen, vaccineren volgende week
-Het is nog niet duidelijk of mensen nu een halve of hele dosis krijgen (maar ik ga uit van een halve dosis)

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Dr June Raine, chief executive of British regulator the MHRA, says the Oxford-AstraZeneca vaccine has been approved for people aged over 18, with two standard doses, four to 12 weeks apart

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Op woensdag 30 december 2020 22:52 schreef W.H.I.S.T.L.E het volgende:
[ afbeelding ]

stond op facebook

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Op woensdag 30 december 2020 22:03 schreef Stephen1985 het volgende:
Voor de fijnproever: een reconstructie over de gang van zaken bij AstraZeneca, n.a.v. gesprekken met tientallen betrokkenen (eerlijk: de kop is iets dramatischer dan het stuk )

https://www.ad.nl/binnenl(...)achtmerrie~a939b09a/

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Vergeleken met de concurrentie hebben Oxford en AstraZeneca ... veel steken laten vallen, zien experts.

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Op woensdag 30 december 2020 22:54 schreef George_of_the_Jungle het volgende:

[..]

Top gedaan weer!

Maar wordt AstraZeneca verhandelt op de beurs?
[..]

Het is wel cru dat een toponderzoekers van een van de hoogst aangeschreven universiteit ter wereld eigenlijk wel wat foutjes hebben gemaakt bij hun onderzoek. Je zou ook kunnen zeggen dat ze ook erg adaptief zijn geweest (toevoegen booster), iets wat mogelijk niet had gehoeven als er een 'normale' tijdlijn was. Dan had men de studie niet zo snel uit kunnen breiden en de data van de eerdere fases kunnen analyseren en fase 2 met een booster plan kunnen starten. Maar dan had men iedereen een booster gegeven na 3-4 weken, en nu blijkt ook dat meer tijd tussen de inentingen beter uitpakt. Ook weer lastig. Uiteindelijk zou je kunnen zeggen dat het a bit messy, but good was. En de veiligheid is niet in het geding geweest, dat wordt altijd onafhankelijk beoordeelt.
Ik ben wel benieuwd naar de huidige data. En nog steeds geen ziekenhuisopnames is wel heel opmerkelijk.

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Op donderdag 31 december 2020 01:01 schreef Middelpunt het volgende:
Ik heb mezelf aangemeld als proefpersoon voor het CureVac vaccin.
Net als Pfizer/BioNtech en Moderna ook een mRNA vaccin. Met als grootste verschil/voordeel dat deze niet op extreme temperaturen bewaard moet worden. Dit vaccin kan minimaal 3 maanden bewaard worden bij +5 graden en zelfs 24 uur op kamertemperatuur.
Dat maakt het logistiek een stuk makkelijker en geschikter voor ons 'fijnmazige netwerk'.

Daarnaast is er ook een veel kleinere dosis nodig waardoor weer waarschijnlijk iets makkelijker veel dosis geproduceerd kunnen worden.
Heb er wel vertrouwen in een hoop dat ik nog in aanmerking kom om mee te doen aan de fase 3 studie (en dan hopelijk geen placebo).

Een nadeel is wel dat als je eenmaal in aanmerking komt voor een vaccin dat al wel goedgekeurd is, dan mag je daar niet aan mee doen. Je kunt immers niet 2 verschillende vaccins tegelijkertijd nemen. Maar de kans dat ik als gezonde 30er snel in aanmerking kom voor een goedgekeurd vaccin lijkt me niet zo groot.

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What if I am called to have a vaccine?

You should first of all decide whether you wish to accept the vaccine that is being offered to you; this is for you to decide on the basis of information provided to you by the NHS and the centre which is offering the vaccine. If you are sure that you do not wish to receive it and are happy to continue in the study then please follow your current visit schedule.

I have been offered an NHS approved vaccine and want to accept it: what do I do?

We will send you the information you need to make these important decisions as you become eligible. If you would like to accept the offer of the NHS vaccine it is important to find out what you received in the study. You might have had two doses of the study vaccine, one dose or you might have been a control, in which case you would have received a different vaccine rather than the COVID-19 one. The only way to find out this information is when the research team contact you when you are eligible to receive a routine vaccine based on national policy. If you have been offered a vaccine as part of national roll out, but have not heard from your study team about unblinding please contact us on the details below. We can undertake a process referred to as ‘unblinding’; this will reveal what you received.

PLEASE ONLY ASK FOR UNBLINDING IF AND WHEN YOU INTEND TO ACCEPT THE NHS APPROVED VACCINE AND NOT UNTIL YOU HAVE BEEN INVITED FOR THE NHS VACCINE

Staying blinded maintains the scientific value of the trial as the primary analysis can only be conducted on blinded participants. Therefore we would like as many people as possible to remain blinded until they are invited to have the approved vaccine. Whilst staying blinded is beneficial for the study it is important for you to do what you believe to be best for you. You are absolutely free to accept the NHS vaccine when it is offered to you. In the event that you are found, on unblinding, to have received the control vaccine or a single dose of the active vaccine, rather than two doses of the active vaccine and we will help you decide what is best for you by providing you with all the information you need. Below is a tool to help you make your decision.

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Op donderdag 31 december 2020 13:46 schreef Momo het volgende:
[ twitter ]

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Op donderdag 31 december 2020 13:46 schreef Momo het volgende:
[ twitter ]

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Covid vaccine: chief medical officers defend rescheduling of second doses

Statement follows outcry from GPs who say cancelling appointments is waste of time and could lead to confusion among patients

The UK’s chief medical officers have defended plans to delay giving the second dose of a Covid vaccine to more than 500,000 people who have received the first jab after an outcry among doctors.

Recipients of the Pfizer/BioNTech vaccine had previously been told there would be a three-week gap between doses, with many already booked in for their second jab.

But the government announced a change to its Covid vaccination strategy on Wednesday, saying second doses of the newly approved Oxford/AstraZeneca vaccine and the previously approved Pfizer/BioNTech jab would now be given up to 12 weeks after the first dose.

The move applies to people scheduled to have their second dose of the Pfizer jab after 4 January, as well as those yet to receive either jab. The government said it hoped the approach would mean as many people as possible would soon have some protection against the disease.

The new regime was backed by the chief medical officers of the four UK nations, with instructions given to health service leaders in England by NHS bosses on Wednesday to postpone many of the scheduled second Pfizer/BioNTech jabs.

The announcement caused controversy, however. Pfizer and BioNTech warned that two doses of their vaccine were required for maximum protection against Covid and that they did not have evidence that the first dose alone offered protection after three weeks.

Azeem Majeed, a professor of primary care and public health at Imperial College London and a practising GP, said he was shocked by the change of plan.

“We’ve got thousands or perhaps tens of thousands of people who have already booked their second jabs, and these are people who are all elderly, so they often have to make special arrangements for their care or have someone to bring them down. Someone is going to have to ring all these patients to cancel their appointments and rebook them, so it is going to create a lot of work for people as well,” he said.

“Clearly the people making these rules are not the ones having to enforce them. I understand the rationale that the government wants to increase the vaccine supply to make sure more people are immunised, but I think that could have been done for people starting from now, rather than cancelling the ones who have already been booked in, which is very disruptive.”

In a joint statement on Thursday night the chief medical officers stood by their decision, although they acknowledged that it would “distress patients who were looking forward to being fully immunised”. They added: “However, we are all conscious that for every 1,000 people boosted with a second dose of Covid-19 vaccine in January (who will as a result gain marginally on protection from severe disease), 1,000 new people can’t have substantial initial protection which is in most cases likely to raise them from 0% protected to at least 70% protected.”

Earlier, one doctor who spoke to the Guardian on condition on anonymity said they hoped to continue with the original schedule for the second dose rather than cancelling appointments, saying that to do otherwise would put their most vulnerable patients at risk and break promises to patients.

Alison Bolam, a GP at Horfield health centre in Bristol, said her practice would take a similar approach. “If we try to ring and cancel 1,000 80-year-olds, and then ring 1,000 75-year-olds and ask them to come in instead, we risk wasting vaccine because we don’t have the staff capacity to do that with the bank holiday in the way,” she said. “If anyone gets the first vaccine now, the second one will be 10 to 12 weeks later, but for anybody who has already had it, they will get their second vaccine as originally scheduled.”

The British Medical Association said it was unreasonable and unfair to expect practices to cancel and rebook appointments for patients to have their second dose.

The chair of the BMA’s GP committee, Dr Richard Vautrey, said: “Local leaders are telling us that is unprofessional and impractical to amend the appointments for thousands of frail, elderly patients, particularly those booked and who have already made arrangements to have their second vaccination in the next two weeks.”

Vautrey called on the government to publish a scientifically validated justification for the new approach, adding that rebooking appointments would cause huge logistical problems.

The Guardian understands a number of NHS clinical commissioning groups were holding meetings on Thursday on the issue, to decide how to proceed.

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Op donderdag 31 december 2020 21:46 schreef capricia het volgende:
En als dit klopt hebben ze eigenlijk niemand effectief ingeënt in de UK:
[ twitter ]
Ik zou ook woedend zijn. De tweede dosis van het vaccin moet rond 21 dagen toegediend worden. Maar de Britse politiek verschuift het naar 12 weken. Pfizer geeft zelf aan dat er geen data is dat je na die 21 dagen nog beschermd bent.

(Crosspost uit POL)