https://www.eaaci.org/res(...)onavirusallergy.htmlttps://onlinelibrary.wiley.com/doi/epdf/10.1111/all.14238
Allergic diseases, asthma and COPD are not risk factors for SARS-CoV-2 infection. Elder age, high number of comorbidities and more prominent laboratory abnormalities were associated with severe patients.
ORIGINAL ARTICLE: EPIDEMIOLOGY AND GENETICS  Free Access
Clinical characteristics of 140 patients infected by SARS‐CoV‐2 in Wuhan, China
Jin‐jin Zhang  Xiang Dong  Yi‐Yuan Cao  Ya‐dong Yuan  Yi‐bin Yang  You‐qin Yan  Cezmi A. Akdis  Ya‐dong Gao
First published:19 February 2020 
https://doi.org/10.1111/all.14238This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/all.14238
Background
Coronavirus Disease 2019 (COVID‐19) caused by Severe Acute Respiratory Syndrome Coronavirus ‐2 (SARS‐CoV‐2) infection has been widely spread. We aim to investigate the clinical characteristic and allergy status of patients infected by SARS‐CoV‐2.
Methods
Electronical medical records including demographics, clinical manifestation, comorbidities, laboratory data and radiological materials of 140 hospitalized COVID‐19 patients, with confirmed result of SARS‐CoV‐2 viral infection were extracted and analysed.
Results
An approximately 1:1 ratio of male (50.7%) and female COVID‐19 patients was found, with an overall median age of 57.0 years. All patients were community acquired cases. Fever (91.7%), cough (75.0%), fatigue (75.0%) and gastrointestinal symptoms (39.6%) were the most common clinical manifestations, whereas hypertension (30.0%) and diabetes mellitus (12.1%) were the most common comorbidities. Drug hypersensitivity (11.4%) and urticaria (1.4%) were self‐reported by several patients. Asthma or other allergic diseases was not reported by any of the patients. Chronic obstructive pulmonary disease (COPD, 1.4%) and current smokers (1.4%) were rare. Bilateral ground glass or patchy opacity (89.6%) were the most common signs of radiological finding. Lymphopenia (75.4%) and eosinopenia (52.9%) were observed in most patients. Blood eosinophil counts correlate positively with lymphocyte counts in severe (r=0.486, p<0.001) and non‐severe (r=0.469, p<0.001) patients after hospital admission. Significantly higher levels of D‐dimer, C‐reactive protein and procalcitonin were associated with severe patients compared to non‐severe patients (all p<0.001).
Conclusion
Detailed clinical investigation of 140 hospitalized COVID‐19 cases 
suggest eosinopenia together with lymphopenia may be a potential indicator for diagnosis. Allergic diseases, asthma and COPD are not risk factors for SARS‐CoV‐2 infection. Elder age, high number of comorbidities and more prominent laboratory abnormalities were associated with severe patients.
											 
			
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