Werkzame stof marijuana (THC) doodt menselijke kankercellen

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Op donderdag 19 maart 2009 18:11 schreef MrLunk het volgende:
@monolith

ja dat en dus dat het Menslijke hersentumoren dood zonder die nare bijwerkingen...

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Op vrijdag 20 maart 2009 11:09 schreef NEC-Nijmegen het volgende:
van roken krijg je kanker, dus het is wel handig dat de wiet dat tegengaat

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Op woensdag 18 maart 2009 18:15 schreef boyv het volgende:

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Medische wiet is er al genoeg, maar da's echt reinste bagger, zelfs de huisarts stemt hiermee in

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Op vrijdag 20 maart 2009 11:09 schreef NEC-Nijmegen het volgende:
van roken krijg je kanker, dus het is wel handig dat de wiet dat tegengaat

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Op zaterdag 21 maart 2009 00:19 schreef Waris7 het volgende:

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Dag Nijmegen Eendracht Combinatie-Nijmegen(!),

Wist je dat het ook mogelijk is wiet te gebruiken zónder het te roken?

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Op zaterdag 21 maart 2009 11:26 schreef Ticker het volgende:

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Vaporizen toch?

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Op zaterdag 21 maart 2009 00:19 schreef Waris7 het volgende:

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Dag Nijmegen Eendracht Combinatie-Nijmegen(!),

Wist je dat het ook mogelijk is wiet te gebruiken zónder het te roken?

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Op woensdag 18 maart 2009 18:15 schreef boyv het volgende:

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Medische wiet is er al genoeg, maar da's echt reinste bagger, zelfs de huisarts stemt hiermee in

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Op maandag 23 maart 2009 15:53 schreef heartz het volgende:

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Maar stel nou dat de coffeeshop geen cannabis meer mag verkopen, denk je niet dat de (normale) blowers die hun wiet bij de coffeeshops haalt opeens medische gebruikers worden?

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Op maandag 23 maart 2009 16:24 schreef Farenji het volgende:
Wiet dat tegen kanker werkt, dat kan helemaal niet!!! Want iedereen weet toch dat wiet slecht is, waarom denk je anders dat het bijna overal ter wereld illegaal is?? En illegale dingen zijn slecht voor je, punt. Daar lijkt me geen enkele discussie over mogelijk.

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This documentary covers a whole lot of ground. It deals with every historical and contemporary aspect of hemp usage and cultivation (mainly in the U.S.), which turns out to be a lot. From describing the production of a fibre much more durable and economic than wood, the documentary discusses hemps multilateral uses as e.g. food products, as a non-polluting fuel and as a pharmaceutical product with much less griveous sideeffects than chemical pharmaceutical products. The film also investigates why America went from a country which produced vast quantities of the non-narcotic industrial hemp, to the complete ban on hemp production in 1938. This story in particular is interesting, and it points out that the large oilbased industries actually had a key role in the aforementioned ban. Food for thought! The conclusion of the documentary could be that hemp may prove to be a valid alternative to both oil and wood in the future.

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Op zaterdag 21 maart 2009 00:19 schreef Waris7 het volgende:

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Dag Nijmegen Eendracht Combinatie-Nijmegen(!),

Wist je dat het ook mogelijk is wiet te gebruiken zónder het te roken?

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Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.
Ramer R, Hinz B.

Institute of Toxicology and Pharmacology, University of Rostock, Schillingallee 70, Rostock D-18057, Germany.

BACKGROUND: Cannabinoids, in addition to having palliative benefits in cancer therapy, have been associated with anticarcinogenic effects. Although the antiproliferative activities of cannabinoids have been intensively investigated, little is known about their effects on tumor invasion. METHODS: Matrigel-coated and uncoated Boyden chambers were used to quantify invasiveness and migration, respectively, of human cervical cancer (HeLa) cells that had been treated with cannabinoids (the stable anandamide analog R(+)-methanandamide [MA] and the phytocannabinoid delta9-tetrahydrocannabinol [THC]) in the presence or absence of antagonists of the CB1 or CB2 cannabinoid receptors or of transient receptor potential vanilloid 1 (TRPV1) or inhibitors of p38 or p42/44 mitogen-activated protein kinase (MAPK) pathways. Reverse transcriptase-polymerase chain reaction (RT-PCR) and immunoblotting were used to assess the influence of cannabinoids on the expression of matrix metalloproteinases (MMPs) and endogenous tissue inhibitors of MMPs (TIMPs). The role of TIMP-1 in the anti-invasive action of cannabinoids was analyzed by transfecting HeLa, human cervical carcinoma (C33A), or human lung carcinoma cells (A549) cells with siRNA targeting TIMP-1. All statistical tests were two-sided. RESULTS: Without modifying migration, MA and THC caused a time- and concentration-dependent suppression of HeLa cell invasion through Matrigel that was accompanied by increased expression of TIMP-1. At the lowest concentrations tested, MA (0.1 microM) and THC (0.01 microM) led to a decrease in invasion (normalized to that observed with vehicle-treated cells) of 61.5% (95% CI = 38.7% to 84.3%, P < .001) and 68.1% (95% CI = 31.5% to 104.8%, P = .0039), respectively. The stimulation of TIMP-1 expression and suppression of cell invasion were reversed by pretreatment of cells with antagonists to CB1 or CB2 receptors, with inhibitors of MAPKs, or, in the case of MA, with an antagonist to TRPV1. Knockdown of cannabinoid-induced TIMP-1 expression by siRNA led to a reversal of the cannabinoid-elicited decrease in tumor cell invasiveness in HeLa, A549, and C33A cells. CONCLUSION: Increased expression of TIMP-1 mediates an anti-invasive effect of cannabinoids. Cannabinoids may therefore offer a therapeutic option in the treatment of highly invasive cancers.

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High concentrations of cannabinoids activate apoptosis in human U373MG glioma cells.
Widmer M, Hanemann CO, Zajicek J.

Clinical Neurology, Institute of Biomedical and Clinical Science, Peninsula Medical School, University of Plymouth, Plymouth, UK.

Cannabinoids bind to two G-protein-coupled receptors, CB1 and CB2, expressed by neurons and cells of the immune system, respectively. Glioma cells (astrocyte-derived brain tumor cells) express cannabinoid receptors, and numerous in vitro and in vivo studies performed in rodents have concluded that apoptosis could be induced by cannabinoids in these cells. Whether this also applies to human cells is controversial; we, therefore, assessed the effect of cannabinoids on human glioma cell viability with the human astrocytoma cell line U373MG. We report here that U373MG human glioma cells are sensitive only to high concentrations of cannabinoids (>5 microg/ml for Delta(9)-THC). Similar concentrations of the compounds promoted a rapid activation of extracellular-regulated kinase and c-Jun NH2-terminal kinase, suggesting that cannabinoid receptors are functional in U373MG cells. Nevertheless, these kinases are not involved in cannabinoid-induced cell death in U373MG cells, insofar as blocking their activation with specific inhibitors does not reduce cell death. CB1 is expressed in U373MG cells and is involved in cannabinoid-induced cell death, in that blocking its activation with a specific antagonist (AM251) almost totally prevented cell death following incubation of the cells with Delta(9)-THC. In addition, as already reported, some cannabinoids may have modest proproliferative properties in U373MG cells. Human U373MG glioma cells are sensitive only to very high, pharmacologically irrelevant concentrations of cannabinoids, so it seems unlikely that cannabinoids would constitute promising molecules for treating malignant astrocytoma; they do not induce glioma cell death at doses that could be applied safely to humans. (c) 2008 Wiley-Liss, Inc.

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Op zaterdag 21 maart 2009 11:38 schreef NEC-Nijmegen het volgende:

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ja, jij?

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Op vrijdag 27 maart 2009 01:47 schreef mediaconsument het volgende:
Weer zo'n vreemd verhaal dat eigenlijk wel in het alcohol topic past.

Hennep werd 100den jaren geleden massaal gebruikt en heeft ladingen goede eigenschappen, echter is dit helemaal verdwenen en zelfs verboden in grote delen van de wereld. Waarom zou je iets zo positiefs verbieden? Dan moet er wel een heel erg negatieve kant aan zitten?