Het grote SARS-CoV-2 topic waar we hysterisch doen #738

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Op maandag 13 juli 2020 12:25 schreef Monolith het volgende:

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Ik heb geen idee waarop je dat baseert anders dan wat vaag gezever over 'deugpartijen'.

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maandag 13 juli 2020 12:20 schreef Momo het volgende:

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martindrent twitterde op zondag 12-07-2020 om 20:36:38 Sommige kroegen in Groningen waren afgelopen weekend tjokvol. Bezoekers kunnen geen afstand houden, zeker niet met een drankje op. Lees meer, met reacties van de burgemeester @:gem_groningen en de horeca ➡️ https://t.co/IKxF9nIA7N Gemaakt met @:Sander_Slager #rtvnoord https://t.co/u4u77eXXCz reageer retweet

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Op maandag 13 juli 2020 12:27 schreef ludovico het volgende:

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Vaag gezever over deugpartijen?

Komop, Christenunie en D66 zien vuur branden als ze FvD horen. Dat snap je zelf ook, die gaan nóóit samenwerken met FvD.

Je hoeft jezelf niet dom voor te doen je snapt best wel welke partijen ik bedoel.

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Op maandag 13 juli 2020 12:29 schreef Momo het volgende:
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Op maandag 13 juli 2020 12:29 schreef Monolith het volgende:
Dat bedoel ik natuurlijk niet. Ik bedoel je loze aantijgingen omtrent de opstelling van D66 en de CU omtrent coronamaatregelen.

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Op maandag 13 juli 2020 12:34 schreef ludovico het volgende:

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Ik zie het beleid van het kabinet, daar maken zij onderdeel van uit, en zie ze weinig weerstand bieden tegen het huidige beleid, ik heb echt helemaal 0.0 reden om aan te nemen dat zij er anders in zouden staan.

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Op maandag 13 juli 2020 12:22 schreef ludovico het volgende:

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PVV zie ik dermate verketterd worden dat al halen ze 65 zetels, dat alleen FvD zijn vingers aan zou branden om daar een kabinet mee te vormen.

FvD zou toch moeten kunnen met CDA en VVD. Deugdrampartijen weggelaten.

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Op maandag 13 juli 2020 12:39 schreef Monolith het volgende:
Ik zie niet in waarom CDA en VVD ook maar ergens iets zouden wijzigen qua koers als het FvD in het kabinet zou zitten.

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Op maandag 13 juli 2020 12:44 schreef ludovico het volgende:

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Omdat je met andere belangen te dealen hebt die een andere richting op wijzen.

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Op maandag 13 juli 2020 12:39 schreef Jaeger85 het volgende:

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Hoe dan? Die partijen staan lijnrecht tegenover elkaar op het gebied van migratie, de EU en het klimaatbeleid. Ook hebben die drie bij lange na geen meerderheid in de eerste kamer.

Het volgende kabinet wordt gewoon weer een middenkabinet.

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Op maandag 13 juli 2020 12:45 schreef Monolith het volgende:

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Welke belangen zijn dat en welke richting wijzen ze op?

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Op maandag 13 juli 2020 12:45 schreef ludovico het volgende:

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Verschrikkelijk eigenlijk dat immigratieskeptisch pas bij FvD zou beginnen in dat geval.
Maar ik denk dat je ongelijk hebt joh, zeker qua achterban zijn ze bij de VVD ook wel klaar met de immigratie en misschien ook wel bij het CDA.

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Op maandag 13 juli 2020 12:33 schreef _serial_ het volgende:
Ja er nog niets in de pers over, maar het lijkt op een clustertje in Rotterdam e.o. (~45 cases afgelopen weekend)

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Op maandag 13 juli 2020 12:46 schreef Jaeger85 het volgende:

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Leuk dat je dit denkt maar dit blijkt nergens uit. Gevalletje wishful thinking!

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Newsweek twitterde op maandag 13-07-2020 om 12:00:16 Scans reveal heart damage in over half of COVID-19 patients in study https://t.co/EYyjOSkemd reageer retweet

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Op maandag 13 juli 2020 12:53 schreef Momo het volgende:

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Newsweek twitterde op maandag 13-07-2020 om 12:00:16 Scans reveal heart damage in over half of COVID-19 patients in study https://t.co/EYyjOSkemd reageer retweet

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On average, the participants were aged 62, and 70 percent were male. Sixty percent of the scans were performed in a critical care setting, such as an ICU unit or emergency room, while the others were carried out in general medicine settings, cardiology, respiratory, or COVID-19 wards. Some 54 percent of the patients had severe COVID-19.

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Op maandag 13 juli 2020 12:53 schreef Momo het volgende:

twitter:

Newsweek twitterde op maandag 13-07-2020 om 12:00:16 Scans reveal heart damage in over half of COVID-19 patients in study https://t.co/EYyjOSkemd reageer retweet

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Op maandag 13 juli 2020 12:57 schreef Elan het volgende:

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Lekker suggestieve titel weer.

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We report findings from the first international survey of echocardiography in patients with confirmed or suspected COVID-19. Data from 1216 patients scanned in 69 countries across six continents demonstrated left or right ventricular abnormalities in half of all patients with COVID-19 undergoing echocardiography, and that these abnormalities were severe in 1 in 7 patients. The majority had non-specific patterns of ventricular dysfunction, although new myocardial infarction, myocarditis, and takotsubo cardiomyopathy were observed in a minority of patients. Echocardiography was reported to directly change patient management in a third of cases including alterations to disease-specific management, haemodynamic support, and the level of care received by the patients.

The simple online format of this survey allowed rapid capture of the echocardiographic findings from a large number of patients with COVID-19 during the pandemic’s peak. This was facilitated by our ability to disseminate and to publicize the survey via social media and through an established global network of imaging specialists. This format allowed us to keep pace with the rapid spread of COVID-19 around the world. Most scans were performed in the current epicentres of the outbreak: the UK, Italy, Spain, France, and the USA. While undoubtedly a global survey, our data remain representative of the current geographical distribution of the virus.

Whilst our previous understanding of how COVID-19 affects the heart was limited to case reports and case series,7–9 consistent epidemiological data have demonstrated that patients with established cardiovascular disease, risk factors, or elevated cardiac biomarkers have an increased susceptibility to infection and an increased risk of severe disease and death.3–6 Severe cardiac disease was observed in 1 in 7 patients across the whole cohort and in 1 in 8 patients without pre-existing cardiac disease. This proportion rose to 1 in 5 when the indication for imaging included raised cardiac biomarkers. The proportion of abnormal echocardiograms and those demonstrating severe cardiac disease were similar after excluding patients with previously established cardiac disease (heart failure, valve disease, or ischaemic heart disease), suggesting that in this population the cardiac abnormalities relate to COVID-19 infection.

The pattern of cardiac injury observed in our survey appears to be consistent with the cardiovascular involvement observed in patients with other severe viral respiratory infections.16–19 Right ventricular abnormalities were observed in a quarter of patients and were more common in patients with more severe symptoms of COVID-19. These are likely to reflect severe respiratory disease, including the viral pneumonia itself, as well as both clinical and subclinical pulmonary thrombo-embolism.20 Left ventricular abnormalities were present in a third of patients and were predominantly non-specific in nature. Further research is required to define the mechanism of this dysfunction as only occasionally were echocardiographic patterns consistent with myocardial infarction, myocarditis, or takotsubo cardiomyopathy. The latter conditions are often difficult to recognize during an isolated echocardiogram, particularly when performed in a critical care setting, and, as such, their true prevalence may have been underestimated.

In a third of patients who underwent echocardiography on clinical indication, imaging was reported to result in an immediate change in patient management. This included changes in disease-specific therapies, such as pericardiocentesis or therapy for heart failure, pulmonary embolism, or acute coronary syndromes. It also contributed to decisions regarding the level of patient care, such as the admission of patients to critical care, and the need for titration of haemodynamic support. In practice, this proportion may have been underestimated as echocardiographers may not have fully appreciated the consequences of their scan at the time of imaging. In addition, a majority of patients had echocardiography performed in an intensive care unit. In this setting, optimization of management may have been previously instituted or changes in management limited by severe respiratory or haemodynamic compromise. Few previous studies have reported the impact of echocardiography on changes in management, and none has been performed in a critical care setting.21 To put our findings into context, Bethge et al. report in an outpatient setting that whilst 22% of patients had abnormal findings, management changed in only 3% of patients.22 Finally, we suggest that information supporting the continuation of a management strategy may be as clinically relevant as information that leads to the initiation of an alternative strategy.

The complex logistics involved in performing echocardiography in patients with COVID-19 and the risk of virus transmission necessitates robust selection of patients for imaging.23 Our data do not imply that all patients with COVID-19 require an echocardiogram. Indeed, patients undergoing echocardiography here had clearly defined clinical indications. Our data suggest that cardiac biomarkers may help improve the selection of patients for imaging, with elevated BNP and cardiac troponin concentrations independent predictors of left and right ventricular abnormalities, respectively. Building on this study, there is now a need for future imaging and biomarker studies to systematically investigate the cardiovascular manifestations of COVID-19, and to establish their true prevalence. The CAPACITY-COVID European Registry aims to determine the role of cardiovascular disease in the COVID-19 pandemic through standardized large-scale data collection.24 Imaging with echocardiography and cardiovascular magnetic resonance following recovery from COVID-19 will be more readily achievable and will be well placed to define any residual cardiac damage caused by the condition. Similarly, studies investigating whether cardiac biomarkers can better direct clinical imaging and improve patient outcomes would be welcome.

Our study suffers from the usual limitations associated with an observational survey. Whilst by design we sought to conduct a rapid survey capturing key echocardiographic findings during the pandemic’s peak, this limited the amount and granularity of the data we could capture. We are reliant on operator-reported findings, as is common in clinical practice, and acknowledge that definitive assessment and core lab verification of cardiac function with echocardiography in critically ill patients is challenging. A proportion of the data was collected from free text-fields, and as such may be biased and represent an underestimate of these findings or clinical variables. Additionally, this survey is subject to substantial case selection bias. For example, we do not know the prevalence of abnormalities in those who did not undergo scanning. In view of the complex logistics around scanning, echocardiography was probably limited to those with clear clinical indications or those with increased disease severity. Furthermore, the use of echocardiography has probably decreased in the current pandemic due to concerns over viral transmission, and this may further contribute to the selection of patients for scanning. We did not capture patient outcomes, but many of the relevant outcomes have yet to occur. Finally, there were relatively few data from certain countries, including China. As the survey continues, we will seek to better target and gather more information from these countries, with further reports to follow.

In this global survey, cardiac abnormalities were observed in half of all COVID-19 patients undergoing echocardiography. Abnormalities were often unheralded or severe, and imaging changed management in one-third of patients.