quote:
Spanish scientist finds cure for pancreatic cancer in major medical breakthrough
A Spanish research team says it has developed a treatment that completely eliminated the most aggressive form of pancreatic cancer in laboratory mice, raising fresh hopes against one of the deadliest cancers. The study, led by Mariano Barbacid at Spain’s Spanish National Cancer Research Centre, found that a newly designed triple-drug therapy wiped out pancreatic tumours with no relapse seen after treatment. After six years of work, researchers reported that the animals showed minimal side effects and no tumour recurrence, results that mark one of the most promising advances yet in pancreatic cancer research.
Pancreatic cancer and the therapy behind the breakthrough
Pancreatic cancer, particularly pancreatic ductal adenocarcinoma, is among the deadliest malignancies due to its resistance to treatment, dense tumour microenvironment, and late diagnosis. Standard therapies often fail because tumours rapidly adapt, bypassing single-target drugs.The CNIO therapy takes a different approach. Instead of attacking one pathway, it combines three drugs to shut down multiple tumour survival mechanisms simultaneously. According to the researchers, this strategy prevents cancer cells from rewiring themselves, a common cause of treatment failure.Barbacid has previously argued that pancreatic cancer cannot be defeated with a single-drug strategy.
This tumour, he has said in earlier research discussions, is extraordinarily adaptable, and only coordinated inhibition of multiple pathways can produce lasting responses.
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