Onderzoek: Ivermectin uitstekend middel in strijd tegen Corona

Favorable outcome on viral load and culture viability using Ivermectin in early treatment of non-hospitalized patients with mild COVID-19 – A double-blind, randomized placebo-controlled trial

Background
Ivermectin, an anti-parasitic agent, also has anti-viral properties. Our aim was to assess whether ivermectin can shorten the viral shedding in patients at an early-stage of COVID-19 infection.

Methods
The double-blinded trial compared patients receiving ivermectin 0·2 mg/kg for 3 days vs. placebo in non-hospitalized COVID-19 patients. RT-PCR from a nasopharyngeal swab was obtained at recruitment and then every two days. Primary endpoint was reduction of viral-load on the 6th day (third day after termination of treatment) as reflected by Ct level>30 (non-infectious level). The primary outcome was supported by determination of viral culture viability.

Results
Eighty-nine patients were eligible (47 in ivermectin and 42 in placebo arm). Their median age was 35 years. Females accounted for 21·6%, and 16·8% were asymptomatic at recruitment. Median time from symptom onset was 4 days. There were no statistical differences in these parameters between the two groups.

On day 6, 34 out of 47 (72%) patients in the ivermectin arm reached the endpoint, compared to 21/ 42 (50%) in the placebo arm (OR 2·62; 95% CI: 1·09-6·31). In a multivariable logistic-regression model, the odds of a negative test at day 6 was 2.62 time higher in the ivermectin group (95% CI: 1·06–6·45). Cultures at days 2 to 6 were positive in 3/23 (13·0%) of ivermectin samples vs. 14/29 (48·2%) in the placebo group (p=0·008).

Conclusions
There were significantly lower viral loads and viable cultures in the ivermectin group, which could lead to shortening isolation time in these patients.

https://www.medrxiv.org/content/10.1101/2021.05.31.21258081v1

Ivermectin Wins in India

News of India's defeat of the Delta variant should be common knowledge. It is just about as obvious as the nose on one's face. It is so clear when one looks at the graphs that no one can deny it.

Yet, for some reason, we are not allowed to talk about it. Thus, for example, Wikipedia cannot mention the peer-reviewed meta-analyses by Dr. Tess Lawrie or Dr. Pierre Kory published in the American Journal of Therapeutics.

https://www.thedesertrevi(...)75-d7b0b1f2ff67.html

Wikipedia is not allowed to publish the recent meta-analysis on Ivermectin authored by Dr. Andrew Hill. Furthermore, it is not allowed to say anything concerning www.ivmmeta.com showing the 61 studies comprising 23,000 patients which reveal up to a 96% reduction in death [prophylaxis] with Ivermectin.

https://en.wikipedia.org/wiki/Talk%3AIvermectin

One can see the bias in Wikipedia by going on the "talk" pages for each subject and reading about the fierce attempts of editors to add these facts and the stone wall refusals by the "senior" editors who have an agenda. And that agenda is not loyalty to your health.

The easy way to read the “talk” page on any Wikipedia subject is to click the top left “talk” button. Anyone can then review the editors’ discussions.

There is a blackout on any conversation about how Ivermectin beat COVID-19 in India. When I discussed the dire straits that India found itself in early this year with 414,000 cases per day, and over 4,000 deaths per day, and how that evaporated within five weeks of the addition of Ivermectin, I am often asked, "But why is there no mention of that in the news?"

Yes, exactly. Ask yourself why India’s success against the Delta variant with Ivermectin is such a closely guarded secret by the NIH and CDC. Second, ask yourself why no major media outlets reported this fact, but instead, tried to confuse you with false information by saying the deaths in India are 10 times greater than official reports.

https://www.npr.org/secti(...)imes-the-official-co

Perhaps NPR is trying so hard because NPR is essentially a government mouthpiece. The US government is “all-in” with vaccines with the enthusiasm of a 17th century Catholic Church “all-in” with a Geocentric Model of the Universe disputing Galileo. Claiming that India’s numbers are inaccurate might distract from the overwhelming success of Ivermectin.

But in the end, the truth matters. It mattered in 1616, and it matters in 2021.



The graphs and data from the Johns Hopkins University CSSE database do not lie. On the contrary, they provide a compelling trail of truth that no one can dispute, not even the NIH, CDC, FDA, and WHO.

Just as Galileo proved with his telescope that the earth was NOT the center of the Universe in 1616; today, the data from India shows that Ivermectin is effective, much more so than the vaccines. It not only prevents death, but it also prevents COVID infections, and it also is effective against the Delta Variant.

In 1616, you could not make up the telescopic images of Jupiter and its orbiting moons, nor could you falsify the crescent-shaped images of Venus and Mercury. These proved that the earth was NOT the center of the Universe – a truth the Catholic Church could not allow.

Likewise, the massive drop in cases and deaths in India to almost nothing after the addition of Ivermectin proved the drug's effectiveness. This is a truth that the NIH, CDC, and FDA cannot allow because it would endanger the vaccine policy.

Never mind that Ivermectin would save more lives with much less risk, much less cost, and it would end the pandemic quickly.

Let us look at the burgundy-colored graph of Uttar Pradesh. First, allow me to thank Juan Chamie, a highly-respected Cambridge-based data analyst, who created this graph from the JHU CSSE data. Uttar Pradesh is a state in India that contains 241 million people. The United States’ population is 331 million people. Therefore, Uttar Pradesh can be compared to the United States, with 2/3 of our population size.

This data shows how Ivermectin knocked their COVID-19 cases and deaths - which we know were Delta Variant - down to almost zero within weeks. A population comparable to the US went from about 35,000 cases and 350 deaths per day to nearly ZERO within weeks of adding Ivermectin to their protocol.

By comparison, the United States is the lower graph. On August 5, here in the good ol’ USA, blessed with the glorious vaccines, we have 127,108 new cases per day and 574 new deaths.

Let us look at the August 5 numbers from Uttar Pradesh with 2/3 of our population. Uttar Pradesh, using Ivermectin, had a total of 26 new cases and exactly THREE deaths. The US without Ivermectin has precisely 4889 times as many daily cases and 191 times as many deaths as Uttar Pradesh with Ivermectin.

It is not even close. Countries do orders of magnitude better WITH Ivermectin. It might be comparable to the difference in travel between using an automobile versus a horse and buggy.

Uttar Pradesh on Ivermectin: Population 240 Million [4.9% fully vaccinated]

COVID Daily Cases: 26

COVID Daily Deaths: 3

The United States off Ivermectin: Population 331 Million [50.5% fully vaccinated]

COVID Daily Cases: 127,108

COVID Daily Deaths: 574

Let us look at other Ivermectin using areas of India with numbers from August 5, 2021, compiled by the JHU CSSE:

Delhi on Ivermectin: Population 31 Million [15% fully vaccinated]

COVID Daily Cases: 61

COVID Daily Deaths: 2

Uttarakhand on Ivermectin: Population 11.4 Million [15% fully vaccinated]

COVID Daily Cases: 24

COVID Daily Deaths: 0

Now let us look at an area of India that rejected Ivermectin.

https://www.thehindu.com/(...)/article34561235.ece

Tamil Nadu announced they would reject Ivermectin and instead follow the dubious USA-style guidance of using Remdesivir. Knowing this, you might expect their numbers to be closer to the US, with more cases and more deaths. You would be correct. Tamil Nadu went on to lead India in COVID-19 cases.

https://www.thedesertrevi(...)11-ab378d521f9a.html

Tamil Nadu continues to suffer for its choice to reject Ivermectin. As a result, the Delta variant continues to ravage their citizens while it was virtually wiped out in the Ivermectin-using states. Likewise, in the United States, without Ivermectin, both the vaccinated and unvaccinated continue to spread the Delta variant like wildfire.

https://www.cnn.com/2021/(...)-thursday/index.html

Tamil Nadu off Ivermectin: Population 78.8 Million [6.9% fully vaccinated]

COVID Daily Cases: 1,997

COVID Daily Deaths: 33

Like the JHU CSSE data, Galileo's telescope did not lie either, and the truth can usually be found in plain sight. Ivermectin works, and it works exceedingly well. Harvard-trained virologist Dr. George Fareed and his associate, Dr. Brian Tyson of California's Imperial Valley, have saved 99.9% of their patients with a COVID Cocktail that includes Ivermectin. They have released versions of their new book published in the Desert Review that everyone should read.

https://www.thedesertrevi(...)51-cf0d67e94c25.html

I could talk about how every one of my patients who used Ivermectin recovered rapidly, about my most recent case who felt 90% better within 48 hours of adding the drug, but I won't. I could write about how Wikipedia censors more than Pravda, about how you should always read the "talk" section of EVERY Wikipedia article to go behind the scenes and understand what the editors DO NOT want you to read, but I will refrain.

I could write about VAERS and how it is so much easier to navigate by following Open VAERS or how Wikipedia has unfairly portrayed Dr. Peter McCullough, one of the world's sharpest and most credible doctors. But I will hold back.

https://www.openvaers.com/

I could also discuss our current cancer treatment system's dangers and how chemotherapy and radiation stimulate cancer stem cells and cancer recurrence. About how this information has been suppressed and how the addition of repurposed drug cocktails can help prevent this, but I digress.

https://www.amazon.com/Su(...)rposed/dp/0998055425

I could recite the history of early outpatient treatment of COVID-19 with repurposed drugs, including Ivermectin, with all the specifics, and EXACTLY WHY this lifesaving information has been censored, but instead, I will leave researching these topics to each of you readers as individuals.

https://www.amazon.com/Iv(...)R-Hope/dp/1737415909

Because you already know what will happen if you simply sit back and swallow what the media are feeding you. You MUST question what the government tells you, and always DO YOUR OWN research.

Following the 1616 Inquisition of Galileo, the Pope banned all books and letters that argued the sun was the center of the Universe instead of the Earth. Similarly, today, the FDA and WHO have banned any use of Ivermectin for COVID outside of a clinical trial.

https://www.fda.gov/consu(...)-or-prevent-covid-19

https://www.who.int/news-(...)thin-clinical-trials

YouTube and Wikipedia both consider Ivermectin for COVID as heresy.

“YouTube doesn’t allow content that spreads medical misinformation that contradicts local health authorities or the World Health Organization’s (WHO) medical information about COVID-19… Treatment misinformation: claims that Ivermectin is an effective treatment for COVID-19.”

Wikipedia defines heresy as: “any belief or theory that is strongly at variance with established beliefs or customs, in particular the accepted beliefs of a church or religious organization. The term is usually used in reference to violations of important religious teachings, but is also used of views strongly opposed to any generally accepted ideas. A heretic is a proponent of heresy.”

Heresy is disagreeing with the government, or their health authority, even if they are all wrong and even if their policies harm people. Today we no longer call it heresy; it is labeled as misinformation.

Galileo was found guilty of heresy and sentenced on June 22, 1633, to formal imprisonment, although this was commuted to house arrest, under which he remained for the rest of his life.

On August 7, 2021 Medpage Today published a new quiz, “Can COVID Misinformation Cost You Your Medical License?”

https://www.medpagetoday.com/quizzes/news-quiz/93943

https://www.thedesertrevi(...)ea-77d5e2519364.html

Ivermectin Wins in Court Again: For Human Rights

One dose of Ivermectin was all it took to get 81-year-old John Swanson off the ventilator. John’s wife Sandra could not believe it. His story is remarkably similar to other cases of patients who were on their way out with advanced COVID-19 but saved when Ivermectin was added.

Ralph Lorigo is the lawyer who now has won three court orders forcing New York hospitals to administer Ivermectin to dying patients. Incredibly, these three hospitals and their lawyers fought against the patients, arguing they did not have the right to receive the drug despite a valid prescription written by their doctors. In essence, the argument was that they did not have the right to try a potentially life-saving medication.

In each of the three cases, the New York State Supreme Court Justices sided with the patient, and in each of the three cases, the patients made near-miraculous recoveries after the Ivermectin was given. In each case, these patients were in the Intensive Care Unit on ventilators, unable to breathe on their own, and universally, after the drug was given, they rapidly improved and were able to breathe on their own.

Judith Smentkiewicz made national news in January when her family hired Lorigo after the hospital refused a fourth dose of Ivermectin. Smentkiewicz's son and daughter called Ivermectin a "miracle drug" in court papers. Attorney Lorigo and his associate Jon F. Minear reported, “This lady was on a ventilator, literally on her deathbed, before she was given this drug. As far as we’re concerned, the judge’s order saved this woman’s life.”

The family of Glenna "Sue" Dickinson happened to see a newspaper article of Judith's remarkable story, and they decided to try Ivermectin as well.

Sue Dickinson, 65, contracted COVID-19 on January 7, 2021. She suffered progressive worsening and was admitted to Rochester General Hospital on January 12. She continued to worsen and was placed on a ventilator on January 17. The hospital staff advised that her chances of survival were about 40 percent.

With nothing to lose, Natalie Kingdollar, Dickinson’s daughter, reached out to their family doctor, Tom Madejski, who wrote the prescription. The hospital refused to give Sue the Ivermectin. The legal team of Lorigo and Minear drafted an affidavit from Dr. Madejski and sought an injunction. State Supreme Court Justice Frank Caruso ordered the hospital to provide the Ivermectin.

Dickinson, like Swanson, and Smentkiewicz, came off the ventilator and improved as well. The family reported on Facebook that, "She’s making progress each day, and it’s Ivermectin and God making this happen.” She has since been released from the hospital.

Ivermectin is widely used by physicians, as there are now 51 studies from around the world, with 50 showing clear benefit and one showing neutral. However, the lone study showing a neutral effect was roundly criticized as flawed in an open letter signed by a group of 120 physicians.

Experts worldwide have called for the global and systematic use of Ivermectin to prevent and treat COVID-19. Physicians have recently written about a profit motive by regulatory agencies and Big Pharma to block cheap, safe, and effective treatments like Ivermectin and HCQ in favor of experimental and perhaps more dangerous and arguably less effective vaccines and medicines like Remdesivir. With Remdesivir costing $3,100 per dose and not reducing deaths, the choice of Ivermectin is a no-brainer say many doctors.

Ivermectin costs about $2 per dose. It is safer than Tylenol or most vitamins, says Dr. Pierre Kory of the FLCCC Alliance, a group of expert physicians promoting access and information through a nonprofit organization. Dr. Kory and Mr. Lorigo have teamed up to help other hospitalized patients gain access to the life-saving drug.

Dr. Fred Wagshul, a Yale-educated physician, is a pulmonary specialist and directs the Lung Center of America. He is also a founding member of the FLCCC Alliance. Dr. Wagshul notes that the typical dose for hospitalized patients is 0.3 mg of Ivermectin per kg of body weight for four days which works out to nine 3 mg tablets daily for four days in a typical 200-pound patient.

Dr. George Fareed, former Harvard professor, advocates combination therapy of Ivermectin with HCQ in outpatient cases. For the benefit of physician readers, the specific doses are provided in this link.

The big problem is that information promoting Ivermectin is often censored or silenced as quickly as it is provided. Facebook, Reddit, Change.org, YouTube, and others have recently taken down posts on Ivermectin citing violation of "community standards."

Physicians who employ good judgment and scientific studies are considered violators, as well as those who publish factual accounts of Ivermectin-based recovery stories. A recent article exposed the link between large pharmaceutical corporations and government regulatory agencies who have financial entanglements and massive conflicts of interest.

Gaat verder:

https://www.thedesertrevi(...)98-37c06f632875.html

Wat artikelen:

"Ivermectin is best taken as a single dose with a full glass (8 ounces) of water on an empty stomach (1 hour before breakfast), unless otherwise directed by your doctor." https://www.mayoclinic.or(...)per-use/drg-20064397

Meta-analysis on the efficacy of Ivermectin in treating Covid19: https://journals.lww.com/(...)atment_of.98040.aspx

A double-blind, randomized placebo-controlled trial shows that Ivermectin is able to cure covid within 6 days for most people: https://www.medrxiv.org/content/10.1101/2021.05.31.21258081v1

More evidence that Ivermectin treatment leads to much faster recovery from Covid19: https://onlinelibrary.wiley.com/doi/10.1002/jmv.26880

An NIH study reveals that a five-day course of ivermectin for the treatment of COVID-19 may reduce the duration of illness: https://pubmed.ncbi.nlm.nih.gov/33278625/

Ivermectin stops replication of covid: https://www.sciencedirect(...)ii/S0166354220302011

Ivermectin has anti-viral properties: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3888155/

Ivermectin binds to Covid19 proteins to block the virus: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/

Ivermectin safe to give 12mg per day for 5 days: https://www.ijidonline.co(...)0%2932506-6/fulltext

Ivermectin safely administered 60mg per day for 6 months: https://www.tandfonline.c(...)0428194.2020.1786559

Ohio judge orders Cinci hospital to treat COVID-19 patient with Ivermectin, despite CDC warnings

A Butler County judge ruled in favor of a woman last week who sought to force a hospital to administer Ivermectin — an animal dewormer that federal regulators have warned against using in COVID-19 patients — to her husband after several weeks in the ICU with the disease.

Butler County Common Pleas Judge Gregory Howard ordered West Chester Hospital, part of the University of Cincinnati network, to treat Jeffrey Smith, 51, with Ivermectin. The order, filed Aug. 23, compels the hospital to provide Smith with 30mg of Ivermectin daily for three weeks.

The drug was originally developed to deworm livestock animals before doctors began using it against parasitic diseases among humans. Several researchers won a Nobel Prize in 2015 for establishing its efficacy in humans. It’s used to treat head lice, onchocerciasis (river blindness) and others.

Both the U.S. Food and Drug Administration and the Centers for Disease Control and Prevention have warned Americans against the use of Ivermectin to treat COVID-19, a viral disease. It’s unproven as a treatment, they say, and large doses of it can be dangerous and cause serious harm. A review of available literature conducted earlier this month by the journal Nature found there’s no certainty in the available data on potential benefits of Ivermectin.

The drug has grown in popularity among conservatives, fueled by endorsements from allies of former President Donald Trump like U.S. Sen. Ron Johnson, R-Wisc. or Fox News personalities Laura Ingraham and Sean Hannity. The CDC warned reports of poisoning related to use of Ivermectin have increased threefold this year, spiking in July.

Gaat verder:

https://www.news5clevelan(...)despite-cdc-warnings

Ivermectin tablets to be distributed among Uttarakhand residents to prevent Covid, says state govt

The Uttarakhand government has announced that Ivermectin tablets will be distributed among the citizens of the state to prevent the spread of Covid-19.

he Uttarakhand government will be distributing Ivermectin, an antiparasitic drug, among the residents of the state as a preventive medicine against the spread of Covid-19, a senior official said.

The Uttarakhand government’s announcement comes after Goa and Karnataka issued similar directions.

The decision was taken on the recommendation of the state-level clinical technical committee, an order issued by Chief Secretary Om Prakash to all district magistrates said.

The panel has recommended the Ivermectin tablet as “mass chemoprophylaxis” to effectively control the surge of Covid-19 infection apart from the vaccination drive, the order said.

The 12 mg tablets of the drug will be distributed in a kit to all families through the health department and district magistrates, the order said.

Dosage
Usually, Ivermectin tablets have to be taken by adults and those above 15 years twice daily for three days after breakfast and dinner. One person will thus need six tablets and a family of four will need 24 tablets. Hence, each kit will contain two dozen tablets, the order said.

Children between 10-15 years will take only one tablet daily whereas those aged between 2 and 10 years can be administered the drug only after doctor's advice. The tablet cannot be given to children below two years, pregnant women and those suffering from liver diseases, it said.

The kit will come with directions on how to consume the medicine and dosage for different age groups. Information related to the daily distribution of the kits should be sent to the state nodal officer, the order said.

Goa
Goa Health Minister Vishwajit Rane had on Monday said all people above 18 years will be given Ivermectin drug irrespective of their coronavirus status to bring down the number of deaths due to the viral disease.



Gaat verder:

https://www.indiatoday.in(...)t-1801863-2021-05-12

Why COVID-19 is not so spread in Africa: How does Ivermectin affect it?

Abstract
Background: Scientists have so far been unable to determine the reason for the low number of
COVID-19 cases in Africa.

Objective:
To evaluate the impact of ivermectin interventions for onchocerciasis on the morbidity,
mortality, recovery, and fatality rates caused by COVID-19.

Method:
A retrospective statistical analysis study of the impact of ivermectin against COVID-19
between the 31 onchocerciasis-endemic countries using the community-directed treatment with
ivermectin (CDTI) and the non-endemic 22 countries in Africa. The morbidity, mortality, recovery
rate, and fatality rate caused by COVID-19 were calculated from the WHO situation report in Africa.
We investigated the onchocerciasis endemic 31 countries and the non-endemic 22 countries.
Statistical comparisons used by the Welch test of them in the two groups were made.

Results:
The morbidity and mortality were statistically significantly less in the 31 countries using
CDTI. The recovery and fatality rates were not statistically significant difference. The average life
expectancy was statistically significantly higher in the non-endemic countries.

Conclusions:
The morbidity and mortality in the onchocerciasis endemic countries are lesser than
those in the non-endemic ones. The community-directed onchocerciasis treatment with ivermectin is
the most reasonable explanation for the decrease in morbidity and fatality rate in Africa. In areas
where ivermectin is distributed to and used by the entire population, it leads to a significant
reduction in mortality.

https://www.medrxiv.org/c(...).21254377v1.full.pdf

Discovery of berberine, abamectin and ivermectin as antivirals against chikungunya and other alphaviruses

Abstract
Chikungunya virus (CHIKV) is an arthritogenic arbovirus of the Alphavirus genus, which has infected millions of people after its re-emergence in the last decade. In this study, a BHK cell line containing a stable CHIKV replicon with a luciferase reporter was used in a high-throughput platform to screen approximately 3000 compounds. Following initial validation, 25 compounds were chosen as primary hits for secondary validation with wild type and reporter CHIKV infection, which identified three promising compounds.

Abamectin (EC50 = 1.5 μM) and ivermectin (EC50 = 0.6 μM) are fermentation products generated by a soil dwelling actinomycete, Streptomyces avermitilis, whereas berberine (EC50 = 1.8 μM) is a plant-derived isoquinoline alkaloid. They inhibited CHIKV replication in a dose-dependent manner and had broad antiviral activity against other alphaviruses - Semliki Forest virus and Sindbis virus. Abamectin and ivermectin were also active against yellow fever virus, a flavivirus.

These compounds caused reduced synthesis of CHIKV genomic and antigenomic viral RNA as well as downregulation of viral protein expression. Time of addition experiments also suggested that they act on the replication phase of the viral infectious cycle.

https://www.sciencedirect(...)ii/S0166354215300516

Interessant artikel over Ivermectin:

Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations

Over the past decade, the global scientific community have begun to recognize the unmatched value of an extraordinary drug, ivermectin, that originates from a single microbe unearthed from soil in Japan. Work on ivermectin has seen its discoverer, Satoshi Ōmura, of Tokyo’s prestigious Kitasato Institute, receive the 2014 Gairdner Global Health Award and the 2015 Nobel Prize in Physiology or Medicine, which he shared with a collaborating partner in the discovery and development of the drug, William Campbell of Merck & Co. Incorporated.

Today, ivermectin is continuing to surprise and excite scientists, offering more and more promise to help improve global public health by treating a diverse range of diseases, with its unexpected potential as an antibacterial, antiviral and anti-cancer agent being particularly extraordinary.

Gaat verder:

https://www.nature.com/articles/ja201711

Safety and Efficacy of the combined use of ivermectin, dexamethasone, enoxaparin and aspirin against COVID 19

From the first outbreak in Wuhan (China) in December 2019, until today the number of deaths worldwide due to the coronavirus pandemic exceeds eight hundred thousand people and the number of infected people arises to more than 25 million.

No treatment tested worldwide has shown unquestionable efficacy in the fight against COVID 19, according to NICE reports.

We have designed an experimental treatment called IDEA based on four affordable drugs already available on the market in Argentina, based on the following rationale:

- Ivermectin solution at a relatively high dose to lower the viral load in all stages of COVID 19

- Dexamethasone 4-mg injection, as anti-inflammatory drug to treat hyperinflammatory reaction to COVID-infection

- Enoxaparin injection as anticoagulant to treat hypercoagulation in severe cases.

- Aspirin 250-mg tablets to prevent hypercoagulation in mild and moderate cases

Except for Ivermection oral solution, which was used in a higher dose than approved for parasitosis, all other drugs were used in the already approved dose and indication. Regarding Ivermectin safety, several oral studies have shown it to be safe even when used at daily doses much higher than those approved already.

A clinical study has been conducted on COVID-19 patients at Eurnekian Hospital in the Province of Buenos Aires, Argentina. The study protocol and its final outcomes are described in this article. Results were compared with published data and data from patients admitted to the hospital receiving other treatments.

None of the patient presenting mild symptoms needed to be hospitalized. Only one patient died (0.59 % of all included patients vs. 2.1 % overall mortality for the disease in Argentina today; 3.1 % of hospitalized patients vs. 26.8 % mortality in published data). IDEA protocol appears to be a useful alternative to prevent disease progression of COVID-19 when applied to mild cases and to decrease mortality in patients at all stages of the disease with a favorable risk-benefit ratio.

https://www.medrxiv.org/content/10.1101/2020.09.10.20191619v1

Ivermectin treatment for Covid is now supported by 113 studies, 73 of which have been peer reviewed. This includes 63 controlled trials with a total of 26,398 patients, and 31 Randomized Controlled Trials. Here is a direct link to 51 of them

https://www.nature.com/articles/s41429-021-00430-5

https://iv.iiarjournals.org/content/34/5/3023.long

https://www.frontiersin.o(...)icb.2020.592908/full

https://www.futuremedicine.com/doi/10.2217/fvl-2020-0342

https://doi.org/10.2217/fvl-2020-0342

https://www.sciencedirect(...)ii/S0167488911001145

https://www.sciencedirect(...)219307211?via%3Dihub

https://link.springer.com/article/10.1007/s00210-020-01902-5

https://doi.org/10.1038/s41429-020-0336-z

https://www.sciencedirect(...)220302011?via%3Dihub

https://ascpt.onlinelibrary.wiley.com/doi/10.1002/cpt.1909

https://www.researchsquare.com/article/rs-73308/v1

https://doi.org/10.1038%2Fs41579-020-00468-6

https://www.pnas.org/content/112/30/9436

https://doi.org/10.3389%2Ffmicb.2020.592908

https://www.embopress.org/doi/full/10.1093/emboj/16.23.7067

https://academic.oup.com/jid/article/222/5/734/5860442

https://doi.org/10.1038%2Fs41418-020-00633-7

https://journals.plos.org(...)journal.pone.0168170

https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(20)30290-0

https://link.springer.com/article/10.1007%2Fs00011-008-8007-8

https://doi.org/10.1038/sigtrans.2017.23

https://jeccr.biomedcentr(...)86/s13046-019-1251-7

https://www.bmj.com/content/369/bmj.m1443

https://www.nejm.org/doi/10.1056/NEJMoa2015432

https://www.journalofinfection.com/article/S0163-4453(20)30234-6/fulltext

https://www.frontiersin.o(...)immu.2020.00827/full

https://science.sciencemag.org/content/369/6504/718

https://ann-clinmicrob.bi(...)6/s12941-020-00362-2

https://pharmrev.aspetjournals.org/content/72/2/486

https://journals.asm.org/doi/10.1128/JVI.01012-07

https://www.nature.com/articles/s41418-020-00633-7

https://doi.org/10.3390%2Fcancers11101527

https://cancerres.aacrjournals.org/content/76/15/4457

https://rupress.org/jgp/a(...)acilitation-of-Human -P2X4 https://www.frontiersin.o(...)phar.2017.00291/full

https://www.jimmunol.org/content/200/3/1159

https://molmed.biomedcent(...)6/s10020-020-00172-4

https://pubmed.ncbi.nlm.nih.gov/29511601/

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(20)30293-0/fulltext

https://onlinelibrary.wil(...)72-8206.2009.00684.x

https://doi.org/10.1007%2Fs00011-011-0307-8

https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(17)30376-6/fulltext

https://pubmed.ncbi.nlm.nih.gov/22417684/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7502160/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7605516/

https://pubmed.ncbi.nlm.nih.gov/27302166/

https://link.springer.com/article/10.1007/s00210-020-01902-5

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6826853/

https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3636557

https://www.embopress.org/doi/full/10.15252/emmm.202114122

Geweldige website met een heleboel onderzoeksresultaten m.b.t. Ivermecine en Corona:

Ivermectin for COVID-19: real-time meta analysis of 63 studies

-Meta analysis using the most serious outcome reported shows 69% [54-79%] and 86% [75-92%] improvement for early treatment and prophylaxis, with similar results after exclusion based sensitivity analysis and restriction to peer-reviewed studies or Randomized Controlled Trials.

-Statistically significant improvements are seen for mortality, hospitalization, recovery, cases, and viral clearance. 28 studies show statistically significant improvements in isolation. The probability that an ineffective treatment generated results as positive as the 63 studies is estimated to be 1 in 1 trillion.

-While many treatments have some level of efficacy, they do not replace vaccines and other measures to avoid infection. Only 27% of ivermectin studies show zero events in the treatment arm.

-Elimination of COVID-19 is a race against viral evolution. No treatment, vaccine, or intervention is 100% available and effective for all current and future variants. All practical, effective, and safe means should be used. Those denying the efficacy of treatments share responsibility for the increased risk of COVID-19 becoming endemic; and the increased mortality, morbidity, and collateral damage.

-The evidence base is much larger and has much lower conflict of interest than typically used to approve drugs.

-All data to reproduce this paper and sources are in the appendix. See [Bryant, Hariyanto, Kory, Lawrie, Nardelli] for other meta analyses with similar results confirming efficacy.

All 44 ivermectin COVID-19 peer reviewed trials

Link: https://ivmmeta.com/#fig_fpp

Ivermectin shows clinical benefits in mild to moderate COVID19: a randomized controlled double-blind, dose-response study in Lagos

Introduction
In vitro studies have shown the efficacy of Ivermectin (IV) to inhibit the SARS—CoV-2 viral replication, but questions remained as to in-vivo applications. We set out to explore the efficacy and safety of Ivermectin in persons infected with COVID19.

Methods
We conducted a translational proof of concept randomized, double blind placebo controlled, dose response and parallel group study of IV efficacy in RT—polymerase chain reaction proven COVID 19 positive patients. Sixty-two patients were randomized to three treatment groups. (A) IV 6 mg regime, (B) IV 12 mg regime (given Q84 h for 2 weeks) (C, control) Lopinavir/Ritonavir. All groups plus standard of Care.

Results
The Days to COVID negativity (DTN) was significantly and dose dependently reduced by IV (P = 0.0066). The DTN for Control were, = 9.1+/–5.2, for A 6.0 +/– 2.9 and for B 4.6 +/–3.2. Two way repeated measures ANOVA of ranked COVID 19 +/– scores at 0, 84, 168 and252h showed a significant IV treatment effect (P = 0.035) and time effect (P < 0.0001). IV also tended to increase SPO2% compared to controls, P = 0.073, 95% CI—0.39 to 2.59 and increased platelet count compared to C (P = 0.037) 95%CI 5.55—162.55 × 103/ml. The platelet count increase was inversely correlated to DTN (r = –0.52, P = 0.005). No SAE was reported.

Conclusions
12mg IV regime given twice a week may have superior efficacy over 6mg IV given twice a week, and certainly over the non IV arm of the study. IV should be considered for use in clinical management of SARS-COV2, and may find applications in prophylaxis in high risk areas.

https://academic.oup.com/(...)jmed/hcab035/6143037

Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19

Conclusions:
Meta-analyses based on 18 randomized controlled treatment trials of ivermectin in COVID-19 have found large, statistically significant reductions in mortality, time to clinical recovery, and time to viral clearance. Furthermore, results from numerous controlled prophylaxis trials report significantly reduced risks of contracting COVID-19 with the regular use of ivermectin. Finally, the many examples of ivermectin distribution campaigns leading to rapid population-wide decreases in morbidity and mortality indicate that an oral agent effective in all phases of COVID-19 has been identified.

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8088823/

Leugenaars!

AP issues correction after claiming 70% of poison control calls were from ivermectin overdoses, real number is 2%

The Associated Press is facing criticism after issuing a correction to a story claiming that 70% of Mississippi's poison control calls were due to people taking dangerous doses of ivermectin.

"In an article published Aug. 23, 2021, about people taking livestock medicine to try to treat coronavirus, The Associated Press erroneously reported based on information provided by the Mississippi Department of Health that 70% of recent calls to the Mississippi Poison Control Center were from people who had ingested ivermectin to try to treat COVID-19," the AP's correction states.

"State Epidemiologist Dr. Paul Byers said Wednesday the number of calls to poison control about ivermectin was about 2%. He said of the calls that were about ivermectin, 70% were by people who had ingested the veterinary version of the medicine," the correction statement concludes.

Many on social media were quick to criticize the AP's rush to discredit ivermectin with no regard for journalistic integrity.

"The AP reported that 70% of recent calls to the Mississippi Poison Control Center were from people who had ingested ivermectin to try to treat COVID-19. The correction acknowledges that it was actually only 2%," one Twitter user said.

"At this point, if you happen upon an ivermectin/“horse dewormer” story, your safest bet is to assume the media are lying. Really. That needs to be your default setting these days," they added.

Gaat verder:

https://independentchroni(...)ectin-real-number-2/

Pfizer’s new ‘daily pill’ to fight Covid utilizes a protease inhibitor… Ivermectin is also a protease inhibitor…



https://citizenfreepress.(...)-protease-inhibitor/