Nog een post van Reddit die ik hier drop voor mensen die hier mogelijk in willen duiken:
https://old.reddit.com/r/(...)idential_hack_files/Acquired all the confidential internal Pfizer/BioNTech vaccine files from the recent EMA hack (obviously i cant upload those here): some brief parts i dug up and condensed on its safety profile: -it degenerates quickly and deterates past 50% effectiveness when it is out of perfect lab conditions easily (but its supposed to be 97%...)
Discussing distribution at the injection site and to the liver. To the untrained eye it is not clear that the bioluminescence signal is solely liver specific. Although the signal appears to be in the liver region, from the data submitted it cannot be excluded that the bioluminescence signal could include distribution to other organs located in proximity of the liver. Several literature reports indicate that LNP(Lipid nano particles)-formulated RNAs can distribute rather non-specifically to several organs such as spleen, heart, kidney, lung and brain
While no extensive pharmacological assessment has been conducted in rats (only in mouse and non-human primate, with no deeper discussion on the choice of animal models. The immune responses, especially at the injection sites (e.g. oedema (build-up of fluid in the body's tissue), erythema (inflamed blood capillaries), seem to increase with each injection in the studies (n=3). There was a marked increase in acute phase proteins, fibrinogen (most often seen in inflammation) and reduced albumin-globulin ratio ( Associated With The Risk of Cancer Prediction Cancer Mortality Associated With The Risk of Dying From Heart Diseases Predict Poor Outcomes After Stroke Myasthenia Gravis - an autoimmune disorder wherein a person’s antibodies attack their own nerves. This type of nerve damage leads to muscle weakness, drooping eyelids, and trouble speaking Linked to Cognitive Decline (but no increase in cytokines with V8, unclear for V9).
There was also a general increase in immune cells (LUC, neutrophils, eosinophils, basophils) and a decrease in red blood cell parameters (reticulocytes, RGB, HGB, HCT). The spleen was enlarged at both 30ug V9 and 100ug V9 and the lymph nodes were enlarged mostly at 100ug (V8) but also in a few animals at 30g (V9). While an immune response is expected from V8 and V9, the strong reaction of the injection site and immune system in rat is difficult to interpret/risk assess as the vaccine candidate(s) are derived from a novel vaccine platform. There is also the possibility, which is difficult to assess non-clinically or effectively in-silico, that the generated antibodies may react with endogenous proteins(vital to a multitude of metabolic and genomic + processes in the body) . An absence of dose-response designs in the studies increases the difficulty to interpret the effects. As the pharmacokinetic distribution study in rat was limited (mainly giving data on liver), the distribution (and its effects) has to be inferred indirectly from the toxicological studies.
There is some uncertainty in this regard as not all tissues have been investigated in the V8 study and histopathological details are unknown for the V9 study and it is recommended to study as many tissues as possible (the following tissues were not studied: nasal body cavity, clitorial gland, dorsal root ganglion, larynx, mandibular lymph node, tibial nerve, preputial gland, ureter, Zymbal’s gland). While there was pathogenesis in liver, there were some hepatic and/or biliary effects with V8 and V9 (enlarged liver, vacuolation, strongly increased gGT levels at >200% and activity, minor-moderate increase in levels of ALT and ALP), (there 3 indicate possible liver damage) which may be linked to the LNP. The gGT changes were not observed with 30ug V9, which may be due to variant differences and/or a lower dose. the lipids contain an acetamide moiety which has been linked to carcinogenicity in animals, including liver tumors, potentially related to genotoxicity, and liver distribution and functional effects have been observed in rats.
Direct from Pfizer, but they say its safe and all should take it, no proper safety trials on a new technology 'vaccine'
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